Androgeni receptor

Androgeni receptor
Identifikatori
Simbol	AR
Alt. simboli	AR, AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM, androgen receptor
OMIM	313700
Ortolozi	28
UniProt	[https://www.uniprot.org/uniprot/P10275 Q9NUA2 P10275 Q9NUA2]
Ostali podaci
Lokus	Hrom. X [https://omim.org/search/?index=geneMap&search=Xq Band =Xq12{{{bend}}} q Band =Xq12{{{bend}}}{{{lokus_dopunski_podaci}}}]
Pretraga za Strukture [https://swissmodel.expasy.org/repository/uniprot/P10275 Q9NUA2 Swiss-model] Domene [https://www.ebi.ac.uk/interpro/protein/P10275 Q9NUA2 InterPro]

Androgeni receptor
Kristalna struktura domena vezanja liganda ljudskog androgenih receptora vezana za nh2-terminalni peptid androgenih receptora ar20-30 i r1881
Identifikatori
Simbol	AR

Androgeni receptor (AR), poznat i kao NR3C4 (potporodica jedarnih receptora 3, grupa C, član 4), je tip jedarnih receptora^[5] koji se aktivira vezanjem bilo kog od androgenih hormona, uključujući testosteron i dihidrotestosteron^[6] u citoplazmi, a zatim se translocira u jedro. Receptor androgena je u najbližoj vezi sa progesteronskim receptorom, a progestin u većim dozama može blokirati androgeni receptor.^[7][8]

Glavna funkcija receptora androgena je vezanje DNK faktora transkripcije koji regulira ekspresiju gena;^[9] međutim, androgeni receptor ima i druge funkcije.^[10] Geni regulirani androgenom kritični su za razvoj i održavanje muškog spolnog fenotipa.

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2. ^ Gottlieb B, Lombroso R, Beitel LK, Trifiro MA (januar 2005). "Molecular pathology of the androgen receptor in male (in)fertility". Reproductive Biomedicine Online. 10 (1): 42–8. doi:10.1016/S1472-6483(10)60802-4. PMID 15705293.
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7. ^ Bardin CW, Brown T, Isomaa VV, Jänne OA (1983). "Progestins can mimic, inhibit and potentiate the actions of androgens". Pharmacology & Therapeutics. 23 (3): 443–59. doi:10.1016/0163-7258(83)90023-2. PMID 6371845.
8. ^ Raudrant D, Rabe T (2003). "Progestogens with antiandrogenic properties". Drugs. 63 (5): 463–92. doi:10.2165/00003495-200363050-00003. PMID 12600226.
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10. ^ Heinlein CA, Chang C (oktobar 2002). "The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions". Molecular Endocrinology. 16 (10): 2181–7. doi:10.1210/me.2002-0070. PMID 12351684.